LymphedemaV1, Main, Exploration, bibRecord, 003168

Sensitivity and specificity of fluorescence microlymphography for detecting lymphedema of the lower extremity.

Identifieur interne : 003168 ( Main/Exploration ); précédent : 003167; suivant : 003169

Sensitivity and specificity of fluorescence microlymphography for detecting lymphedema of the lower extremity.

Auteurs : Hong H. Keo [Suisse] ; Marianne Schilling ; Roland Büchel ; Ernst Gröchenig ; Rolf P. Engelberger ; Torsten Willenberg ; Iris Baumgartner ; Silvia B. Gretener

Source :

Vascular medicine (London, England) [ 1477-0377 ] ; 2013.

RBID : pubmed:23624356

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie optique (), Jambe (), Lymphoedème (), Lymphographie (), Membre inférieur (), Membre inférieur (anatomopathologie), Mâle, Sujet âgé, Vaisseaux lymphatiques ().
MESH :
- anatomopathologie : Membre inférieur.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Imagerie optique, Jambe, Lymphoedème, Lymphographie, Membre inférieur, Mâle, Sujet âgé, Vaisseaux lymphatiques.

English descriptors

KwdEn :
- Adult, Aged, Female, Humans, Leg (surgery), Lower Extremity (pathology), Lower Extremity (surgery), Lymphatic Vessels (surgery), Lymphedema (surgery), Lymphography (methods), Male, Middle Aged, Optical Imaging (methods).
MESH :
- methods : Lymphography, Optical Imaging.
- pathology : Lower Extremity.
- surgery : Leg, Lower Extremity, Lymphatic Vessels, Lymphedema.
- Adult, Aged, Female, Humans, Male, Middle Aged.

Abstract

Fluorescence microlymphography (FML) is used to visualize the lymphatic capillaries. A maximum spread of the fluorescence dye of ≥ 12 mm has been suggested for the diagnosis of lymphedema. However, data on sensitivity and specificity are lacking. The aim of this study was to investigate the accuracy of FML for diagnosing lymphedema in patients with leg swelling. Patients with lower extremity swelling were clinically assessed and separated into lymphedema and non-lymphatic edema groups. FML was studied in all affected legs and the maximum spread of lymphatic capillaries was measured. Test accuracy and receiver operator characteristic (ROC) analysis was performed to assess possible threshold values that predict lymphedema. Between March 2008 and August 2011 a total of 171 patients (184 legs) with a median age of 43.5 (IQR 24, 54) years were assessed. Of those, 94 (51.1%) legs were diagnosed with lymphedema. The sensitivity, specificity, positive and negative likelihood ratio and positive and negative predictive value were 87%, 64%, 2.45, 0.20, 72% and 83% for the 12-mm cut-off level and 79%, 83%, 4.72, 0.26, 83% and 79% for the 14-mm cut-off level, respectively. The area under the ROC curve was 0.82 (95% CI: 0.76, 0.88). Sensitivity was higher in the secondary versus primary lymphedema (95.0% vs 74.3%, p = 0.045). No major adverse events were observed. In conclusion, FML is a simple and safe technique for detecting lymphedema in patients with leg swelling. A cut-off level of ≥ 14-mm maximum spread has a high sensitivity and high specificity of detecting lymphedema and should be chosen.

DOI: 10.1177/1358863X13485505
PubMed: 23624356

Affiliations:

Suisse

Le document en format XML

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<term>Lower Extremity (pathology)</term>
<term>Lower Extremity (surgery)</term>
<term>Lymphatic Vessels (surgery)</term>
<term>Lymphedema (surgery)</term>
<term>Lymphography (methods)</term>
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<term>Lower Extremity</term>
<term>Lymphatic Vessels</term>
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<front><div type="abstract" xml:lang="en">Fluorescence microlymphography (FML) is used to visualize the lymphatic capillaries. A maximum spread of the fluorescence dye of ≥ 12 mm has been suggested for the diagnosis of lymphedema. However, data on sensitivity and specificity are lacking. The aim of this study was to investigate the accuracy of FML for diagnosing lymphedema in patients with leg swelling. Patients with lower extremity swelling were clinically assessed and separated into lymphedema and non-lymphatic edema groups. FML was studied in all affected legs and the maximum spread of lymphatic capillaries was measured. Test accuracy and receiver operator characteristic (ROC) analysis was performed to assess possible threshold values that predict lymphedema. Between March 2008 and August 2011 a total of 171 patients (184 legs) with a median age of 43.5 (IQR 24, 54) years were assessed. Of those, 94 (51.1%) legs were diagnosed with lymphedema. The sensitivity, specificity, positive and negative likelihood ratio and positive and negative predictive value were 87%, 64%, 2.45, 0.20, 72% and 83% for the 12-mm cut-off level and 79%, 83%, 4.72, 0.26, 83% and 79% for the 14-mm cut-off level, respectively. The area under the ROC curve was 0.82 (95% CI: 0.76, 0.88). Sensitivity was higher in the secondary versus primary lymphedema (95.0% vs 74.3%, p = 0.045). No major adverse events were observed. In conclusion, FML is a simple and safe technique for detecting lymphedema in patients with leg swelling. A cut-off level of ≥ 14-mm maximum spread has a high sensitivity and high specificity of detecting lymphedema and should be chosen.</div>
</front>
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Serveur d'exploration sur le lymphœdème

Sensitivity and specificity of fluorescence microlymphography for detecting lymphedema of the lower extremity.

Sensitivity and specificity of fluorescence microlymphography for detecting lymphedema of the lower extremity.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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